An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen
- 9 May 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 126 (6) , 757-759
- https://doi.org/10.1039/b102424h
Abstract
During the evaluation of molecular imprinted polymers (MIPs) prepared against the drug tamoxifen a propranolol-derived MIP was used as a positive control. Surprisingly the propranolol-derived MIP showed considerable selectivity towards tamoxifen, and was indeed much more selective than the MIP prepared using tamoxifen as the imprint molecule. The consequences of this unexpected, cross reactivity for the use of MIPs in analytical chemistry is discussed.Keywords
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