Bromocriptine

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Abstract
BROMOCRIPTINE (2-bromo-alpha-ergocryptine, Parlodel) (Fig. 1), an ergot derivative with dopamine receptor agonist actions that lowers prolactin levels in the blood,1 2 3 4 5 was developed by Flückiger as a compound with powerful action on prolactin but with little toxicity to the vascular system or uterus.6 , 7 The FDA-approved package insert gives as the only indication "the short-term treatment of amenorrhea/galactorrhea associated with hyperprolactinemia due to varied etiologies, excluding demonstrable pituitary tumors." The drug is considered "not indicated in the management of infertility" because "safe use has not been demonstrated in pregnancy." This review will discuss bromocriptine from the broader, British perspective.Mechanism of Action . . .