THE COMPARATIVE EFFECTS OF METACORTANDRACIN, 9-α-FLU0R0HYDR0C0RTIS0NE AND HYDROCORTISONE UPON ACTH SECRETION IN MAN*

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Abstract
Data concerning effects of hydrocortisone, cortisone, metacortandracin, and 9-alpha-fluorohydrocortisone in the adrenogenital syndrome are presented. Depression of excessive 17-ketosteroid excretion was noted with all 4 preparations. 9-Alpha-fluorohydrocortisone appeared to be the most potent; metacortandracin next; followed by hydrocortisone; then cortisone, which was least active on the basis of weight of the required dose. 9-Alpha-fluorohydrocortisone in the doses employed, readily induced toxicity, characterized by fluid retention and edema. Adequate suppression of ketosteroid excretion and clinical management of the adrenogenital patient was easily accomplished by oral preparations. Clinical improvement as manifested by establishment of menstrual periods or regularity of menstrual periods, increase in breast size, and decrease in hair growth also followed administration of each of these corti-coids.

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