Children born after intracytoplasmic sperm injection: population control study

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Abstract
Children between 12 and 24 months old who had been singleton births were identified from a list of couples who had received the treatment and their parents were invited to participate; 123 of 137 families (90%) agreed. Control children, conceived naturally, were recruited from associated nurseries (105/123) or were social peers of cases (18/123). Altogether, 123 children born after intracytoplasmic sperm injection (study children) and 123 control children were seen. Children were matched for social class, maternal educational level, region, sex, and race but not maternal age. Multiple births were excluded to avoid confounding factors. Primary outcome measures were developmental scoring on the Griffiths scales of mental development3 and rates of congenital abnormalities. The Griffiths scales are an objective method of assessing development which uses five subscales. All subscales have a normal mean score of 100 (75-125, SD 1).