Combination of Potassium Iodide and Propranolol in Preparation of Patients with Graves' Disease for Thyroid Surgery

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Abstract
We assessed the efficacy of the combination of propranolol and potassium iodide in the preparation of patients with Graves' disease for thyroid surgery. Potassium iodide was given orally in a dose of 60 mg three times a day for 10 days before operation in 10 patients who were already receiving propranolol. In contrast to previous experience with either drug used singly, the combined regimen caused a significant fall in mean serum total thyroxine and triiodothyronine to levels in the euthyroid range before operation (P<0.001). There was also a significant fall (P<0.05) before operation and a transient rise after operation in serum reverse triiodothyronine.