Reciprocal stimulation of negatively selected high-responder and low-responder T cells in virus-infected recipients.

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Abstract
After alloreactive potential depletion, immunologically naive T [thymus-derived] cells from C57BL/6J (Kb-Db) mice (B6) can be induced to respond to vaccinia virus in the context of H-2KK and H-2Db when stimulated in B10.A(4R) (Kk-Kb) recipients. Negatively selected B10.A(2R) (Kk-Db) T cells respond to H-2Db-vaccinia virus but not to H-2Kb-vaccinia virus when primed in an irradiated B6 environment. The B6 mouse strain responds highly to vaccinia virus associated with H-2Db, whereas the B10.A(2R) and B10.A(4R) recombinants are low responders. Responsiveness in the context of H-2Db is recognized when the only homology between T cell and recipient is at the H-2D locus and is suppressed when H-2Kk is present in both situations. The fact that negatively selected H-2Kb-Db T cells can be induced to recognize H-2Kk-vaccinia virus may reflect existence of an altered self complex which is recognized via a single receptor, perhaps drawn from an alloreactive T cell repertoire. T cell responsiveness patterns are sometimes not totally constrained by the H-2 antigen spectrum encountered in thymus.

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