An angioscopic imaging system involves several interfaces among its optical and mechanical components. For best results, the system should be optimized at least to the level of its weakest link. As with any multi-component system, the process of optimizing an angioscope system begins with careful analysis of the functional properties of each component followed by a design study to determine how the components work together. The component technology has evolved to provide sufficient image quality so that the physician-user can use the information for diagnostic applications.