Experiences with Ethamivan, a New Respiratory Stimulant and Analeptic Agent

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Abstract
THE purpose of this report is to describe our experiences with ethamivan (vanillic diethylamide [Emivan]) in the therapy of disorders associated with respiratory depression. Forty-three adult patients with clinical evidences of diffuse impairment of pulmonary air exchange were studied. These included 7 with barbiturate intoxication, 27 with severe chronic obstructive pulmonary emphysema, and 9 miscellaneous cases. Arterial blood was sampled anaerobically using a Cournand needle in 10 of the subjects with pulmonary emphysema. Gas contents were obtained by the method of Van Slyke and Neill1and the arterial CO2tension (Paco2) calculated from a line chart based on the Henderson-Hasselbach equation,2after the pH was determined with a Metrohm pH meter. Barbiturate Intoxication Our experiences with the 7 cases of barbiturate intoxication are summarized in Table 1. In the severely depressed patients (1 and 6), priming doses of 400 and 500 mg. of ethamivan were

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