Dopaminergic mechanism in generalized photosensitive epilepsy

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Abstract
Apomorphine, a dopamine receptor agonist, blocked epileptic photosensitivity in patients with primary corticoreticular epilepsy. This effect was not modified by naloxone, a narcotic antagonist, suggesting that apomorphine acts on cerebral dopaminergic receptors. Apomorphine did not block spontaneous spike-and-wave discharges in patients with nonphotosensitive primary corticoreticular epilepsy. The different actions of apomorphine on spontaneous and phot-ically induced spike-and-wave activity suggest that there is a selective dopaminergic mechanism in human epileptic photosensitivity.

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