Perianal Paget's disease associated with cloacogenic carcinoma

Abstract
A case of perianal Paget''s disease associated with a cloacogenic carcinoma is presented. There was no clinical evidence of the Paget''s disease, which was confined to a very small area. The points of particular interest were the association of Paget''s disease with a cloacogenic carcinoma and the dissimilarity between the pagetoid cells and the carcinoma cells. The histologic differences between the 2 cell types support the view that perianal Paget''s disease and underlying carcinomas represent a multicentric reaction to an unknown stimulus.

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