Changes in the Mix of AIDS-Defining Conditions

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Abstract
Antiretroviral therapy and chemoprophylaxis are changing the natural history of infection with the human immunodeficiency virus (HIV), with a change in the pattern of initial AIDS-defining illnesses1,2 [see Hoover et al. elsewhere in this issue]. In the U.S. military, HIV screening is mandatory. We reviewed the AIDS-defining diagnoses at the Naval Medical Center in San Diego, California, in patients who had been identified as HIV-seropositive or had received a diagnosis of AIDS while on active duty. A trend analysis was performed with a simple linear regression.