ENZYMATIC CHANGES IN RAT THYMUS AFTER INTRAPERITONEAL INJECTIONS OF ADRENOCORTICOTROPIC HORMONE AND CORTICOSTERONE

1 January 1981

journal article
research article

Vol. 2 (6) , 299-304

Abstract

I.p. injection in adult male rats with ACTH (0.6 mU daily for 3 days) brought about a marked decrease in the activities of 4 thymic enzymes studied: glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, isocitric dehydrogenase and malic dehydrogenase. A prominent rise in the levels of these enzymes occurred when ACTH was replaced by corticosterone (1 mg injected daily for 3 days). In adrenalectomized rats, the results were similar to those observed in intact animals. The significance of an increase in transaminase activities after corticosterone treatment, relating to an increase in citric cycle enzymes, is discussed. ACTH may exert an extra-adrenal effect on the thymus.

This publication has 1 reference indexed in Scilit:

STUDIES ON THE EFFECT OF CORTISOL AND CORTICOTROPHIN ON INCORPORATION OF ADENINE-8-14C INTO THE LYMPHATIC TISSUE NUCLEIC ACIDS
Acta Endocrinologica, 1965