A Convergent Synthesis of the tris-Oxazole Ring System in Ulapualide A and Related Marine Metabolites
- 31 December 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 12 (12) , 1342-1344
- https://doi.org/10.1055/s-1997-1056
Abstract
A convergent synthesis of the fully functionalised tris-oxazole system 16, found in the ulapualide family of marine macrolides, involving elaboration of the substituted oxazoles 13 and 8, followed by their coupling to the amide 14 and manipulation of the third oxazole ring via the oxazoline intermediate 15, is described.Keywords
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