Unique cell lines harbouring both Epstein–Barr virus and adult T-cell leukaemia virus, established from leukaemia patients
- 1 September 1982
- journal article
- Published by Springer Nature in Nature
- Vol. 299 (5881) , 367-369
- https://doi.org/10.1038/299367a0
Abstract
Members of three distinct classes of animal virus have been associated with naturally occurring neoplasias in man: Epstein--Barr virus (EBV), a DNA virus belonging to herpesvirus group, papillomavirus, and a novel human RNA (retro) virus, human T-cell leukemia virus or adult T-cell leukaemia (ATL) virus. We have established seven continuous cell lines from ATL patients and 0.1-7% of these cells consistently express ATL-specific antigens (ATLA). EBV-associated nuclear antigen (EBNA) is also found in more than 90% of these cells. We have cloned cells from two of these lines and show here that both ATLA and EBNA were present in the same B-cell clone carrying surface immunoglobulin (sIg).Keywords
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