Abstract
The central nervous system can be involved early in the course of infection with human immunodeficiency virus type 1 (HIV-1).1 2 3 The clinical presentation may be one of meningitis or encephalitis. Several HIV-1 isolates exhibit marked neurotropism.4 5 6 There are indications that intrathecal immune regulatory mechanisms may be activated separately from those of the rest of the body.6 , 7