Class I Integron-BorneblaVIM-1Carbapenemase in a Strain ofEnterobacter cloacaeResponsible for a Case of Fatal Pneumonia
- 1 March 2008
- journal article
- research article
- Published by Mary Ann Liebert Inc in Microbial Drug Resistance
- Vol. 14 (1) , 45-47
- https://doi.org/10.1089/mdr.2008.0765
Abstract
We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobacter cloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. The microorganism was investigated for the presence of metallo- and extended-spectrum β-lactamases. The strain produced two class 1 integrons carrying blaVIM-1 and aadA2 gene cassettes located on chromosomal and plasmidic DNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum β-lactamase. Our results clearly demonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications.Keywords
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