Quantitative 31P MRS of the normal adult human brain. Assessment of interindividual differences and ageing effects
- 1 January 1993
- journal article
- Published by Wiley in NMR in Biomedicine
- Vol. 6 (1) , 53-57
- https://doi.org/10.1002/nbm.1940060109
Abstract
The characteristics of the 31P MR spectra from a large central volume in the brain of 47 healthy adults (aged 25–85 years) were assessed. Spectral parameters were estimated by means of a time‐domain fitting technique. Statistical uncertainties of the estimates were determined by means of the Cramer‐Rao theory and minimized by introducing a priori knowledge into the fitting procedure. Age‐dependency of the spectral parameters was assessed by means of linear regression. Significant differences between individuals were established for some parameters. A significant age‐dependency (p⩽0.001) of ca 20% over the age range considered was found for the intensity of the phosphocreatine resonance line.Keywords
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