Chiral Ligands Containing Heteroatoms; 9.1General Procedures for the Synthesis of Optically Active 1-(2-Pyridyl)alkylamines from α-Amino Acids
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (10) , 972-976
- https://doi.org/10.1055/s-1992-26282
Abstract
General syntheses of 1-(2-pyridyl)alkylamines and N-methyl or N,N-dimethyl-1-(2-pyridyl)alkylamines from optically active α-amino acids are described. The presented procedures are based on catalyzed co-cyclotrimerization of the suitable nitriles with acetylene which can be conducted without loss of optical purity.Keywords
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