Refractory Period and Strophanthin Actions, as Influenced by Four Indole Alkaloids and Two Synthetic Azepinoindoles

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Abstract
The harmala alkaloids har mane and harmine, the iboga alkaloids ibogamine and tabernanthine, and two synthetic azepinoindoles prolong the functional re fractory period of isolated left guinea pig atria. Actions of k-strophanthin in vitro are modified by these drugs, e.g. concentrations for maximal inotropic action and those forcontracture or standstill are increased. Harmane and the azepinoindoles reduce the inotropic activity of strophanthin. Relationships between chemical structure and pharmacological actions are obvious.

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