Concordance of Carcinogenic Response between Rodent Species: Potency Dependence and Potential Underestimation
- 1 March 1992
- journal article
- research article
- Published by Wiley in Risk Analysis
- Vol. 12 (1) , 115-121
- https://doi.org/10.1111/j.1539-6924.1992.tb01314.x
Abstract
The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of the underlying potency or toxicity of the chemicals over which the averaging is performed. Thus, the averaging process dilutes large observed concordances from potent chemicals, and possibly inflates lower observed concordances from weakly active chemicals. Stratification over some measure of potency is suggested as a method for taking these effects into account. Statistical simulations of concordance analyses limited to low-potency ranges are employed to examine the concordance measure in greater detail. It is seen that at low potencies, observed concordance is consistently underestimated, reaching maximum levels of only about 80%.Keywords
This publication has 28 references indexed in Scilit:
- Predicting Rodent Carcinogenicity from Four in vitro Genetic Toxicity Assays: An Evaluation of 114 Chemicals Studied by the National Toxicology ProgramJournal of the American Statistical Association, 1990
- Correlations between bioassay dose-level, mutagenicity to Salmonella, chemical structure and sites of carcinogenesis among 226 chemicals evaluated for carcinogenicity by the U.S. NTPMutation Research Letters, 1990
- Mutagenic and carcinogenic potency indices and their correlationTeratogenesis, Carcinogenesis, and Mutagenesis, 1990
- Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicityEnvironmental and Molecular Mutagenesis, 1990
- Screening for possible human carcinogens and mutagens false positives, false negatives: statistical implicationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- Interspecies extrapolation in carcinogenesis: prediction between rats and mice.Environmental Health Perspectives, 1989
- A blind reanalysis of a random subset of NCI bioassay studies: Agreement between rats and mice Introduction to symposiumFundamental and Applied Toxicology, 1989
- Issues Concerning the Estimation of the TD50Risk Analysis, 1987
- Species correlation in long-term carcinogenicity studiesCancer Letters, 1987
- Tautology or not tautology?Journal of Toxicology and Environmental Health, 1987