TUMOR-REGRESSION AFTER INTRA-LESIONAL INJECTION OF MYCOBACTERIAL COMPONENTS EMULSIFIED IN 2,6,10,15,19,23-HEXAMETHYL-2,6,10,14,18,22-TETRACOSAHEXAENE (SQUALENE), 2,6,10,15,19,23-HEXAMETHYLTETRACOSANE (SQUALANE), PEANUT OIL, OR MINERAL-OIL

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (5) , 1518-1520
Abstract
The influence of mineral oil, squalane, squalene or peanut oil on th antitumor activity of emulsified BCG cell walls or emulsified trehalose-6,6''-dimycolate was studied in mice, each with an established transplant of a syngeneic fibrosarcoma [1023]. Each animal received an intratumoral injection of BCG cell walls (0.6 mg/mouse) or trehalose-6,6''-dimycolate (0.1 mg/mouse) emulsified in 1-10% oil. Emulsions of squalene or squalane but not peanut oil were effective substitutes for mineral oil as carriers of BCG cell walls in the treatment of the tumor. Trehalose-6,6''-dimycolate was therapeutically active when it was incorporated in any of these 4 oils. The number of animals in which tumor regressed completely depended on the concentration of oil in the emulsion.