Gastric cancer: problems in histological diagnosis

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Abstract
The reproducibility of the most recent histological classifications for [human] gastric cancer was studied. A comparison of the results obtained using the criteria of Lauren, Ming, Mulligan and WHO, showed that highest reproducibility was achieved with the WHO classification. An acceptable accuracy in diagnosis for the other 3 classifications was obtained. The study confirms the validity of the WHO criterion for initial diagnosis, while the other classifications should be kept for further specific investigations, such as epidemiological or prognostic studies.