Perinatal induction of medulloblastomas in Syrian golden hamsters by a human polyoma virus (JC).

  • 1 May 1979
    • journal article
    • No. 51,p. 205-8
Abstract
Medulloblastomas, originating from cells of the internal granular layer of the cerebellum, developed in Syrian golden hamsters 3--6 months after inoculation at birth intracerebrally and sc with JC virus, a papovavirus isolated originally from a human case of the demyelinating disease progressive multifocal leukoencephalopathy. The lesion is compared with the human medulloblastoma of childhood. JC virus is the first infectious agent to produce such a neoplasm in any species.

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