SURVIVAL OF PRIMATES IN LETHAL SEPTIC SHOCK FOLLOWING DELAYED TREATMENT WITH STEROID

  • 1 January 1981
    • journal article
    • research article
    • Vol. 8  (3) , 291-300
Abstract
A methylprednisolone sodium succinate (MPSS)/gentamicin sulfate (GS) regimen that prevented death in baboons given a 2 h infusion of LD100 [100% lethal dose] Escherichia coli was developed. Steroid treatment began in that study 30 min after initiation of E. coli. This study determined if baboons would survive if MPSS treatment was delayed until all E. coli were infused and severe hypotension had ensued. Fourteen lightly anesthetized baboons (Papio cynocephalus cynocephalus) were administered E. coli and 7 were then treated with MPSS and GS for 10 h. All nontreated baboons diet; 6 of 7 treated animals survived. In the treated group, hypoglycemia and hypoinsulinemia were reversed, tachycardia was reduced and neutrophil recovery was improved. Baboons with delayed MPSS evidenced diminished perfusion and recovered more slowly than those with earlier MPSS treatment. Primates in septic endotoxin shock are evidently protected with delayed steroid/antibiotic therapy.

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