Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Top Cited Papers
- 12 February 2009
- Vol. 136 (5) , 839-851
- https://doi.org/10.1016/j.cell.2009.01.020
Abstract
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This publication has 41 references indexed in Scilit:
- Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine TumorsClinical Cancer Research, 2008
- Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of miceThe Journal of Physiology, 2004
- Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylasesBiochemical Journal, 2004
- The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesisBlood, 2004
- Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cellsAmerican Journal of Physiology-Cell Physiology, 2004
- Targeting HIF-1 for cancer therapyNature Reviews Cancer, 2003
- VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodiaThe Journal of cell biology, 2003
- Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148The Journal of cell biology, 2003
- The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodelingProceedings of the National Academy of Sciences, 2000
- Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and AngiogenesisCell, 1999