Cylindrical Splitt and Quadrupole Magnetic Field in Application to Continuous-Flow Magnetic Cell Sorting

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Abstract
The quadrupole magnetic field has been used for quadrupole mass spectroscopy and for industrial and mining dry separations. We propose to use it for rapid, continuous-flow cell sorting in biomedical and biotechnological applications. We set out to investigate the performance of such a sorter using the theoretical methods of split-flow thin channel separation (SPLITT). Comparison of theoretical results and preliminary experimental data, using a model system of human peripheral lymphocytes labeled with immunomagnetic colloid, led us to the identification of the most important parameters of the system.