SCHEDULE-DEPENDENT ANTITUMOR EFFECTS OF METHOTREXATE AND 5-FLUOROURACIL

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (1) , 327-328
Abstract
The antitumor effects of methotrexate with 5-fluorouracil against the sarcoma 180 mouse tumor model were schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrexate following 5-fluorouracil. These studies support the hypothesis that methotrexate pretreatment with 5-fluorouracil is synergistic by increasing the amount of thymidylate synthetase bound to the active metabolite of 5-fluorouracil.