Diastereoselective Synthesis of the Hydroxyethylene Dipeptide Isostere of Leu–Val
- 1 November 1989
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 18 (11) , 1993-1996
- https://doi.org/10.1246/cl.1989.1993
Abstract
The synthesis of hydroxyethylene dipeptide isostere of Leu–Val, a transition-state mimic, is described. The key steps of this synthetic approach are the homogeneous asymmetric hydrogenation of γ-keto esters by BINAP–Ru(II) complex, and the construction of a 2(S)-isopropyl unit.Keywords
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