Antineoplastic Agents, 107. Isolation of Acteoside and Isoacteoside from Castilleja linariaefolia
- 1 March 1990
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 53 (2) , 456-458
- https://doi.org/10.1021/np50068a026
Abstract
The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.Keywords
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