In vitro replication through nucleosomes without histone displacement
- 22 February 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 343 (6260) , 719-726
- https://doi.org/10.1038/343719a0
Abstract
A well-characterized set of proteins encoded by bacteriophage T4 replicates DNA in vitro and generates replication forks that can pass nucleo-somes. The histone octamers remain associated with newly replicated DNA even in the presence of excess DNA competitor, and intact nucleosomes re-form on the two daughter DNA helices. It is concluded that nucleosomes are designed to open up transiently to allow the passage of a replication fork without histone displacement.Keywords
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