Chemoprophylaxis of Meningococcal Carriers

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Abstract
For over 20 years sulfadiazine was a model prophylactic agent: when used in closed populations, small amounts of sulfonamide drugs interrupted transmission of meningococci by eradicating the organism from the nasopharynges of asymptomatic carriers, who are the source of most meningococcal illnesses. With the development and spread of sulfonamide-resistant strains several years ago this era of tranquillity came to an abrupt end. The most recent data show that sulfonamide-resistant meningococci now account for over 70 per cent of the reported cases of meningococcal bacteremia and meningitis.1 At present no other chemoprophylactic drug has proved capable of preventing meningococcal disease or . . .

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