The metabolism of dimethylamphetamine in rat and man
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (8) , 965-971
- https://doi.org/10.3109/00498258709044195
Abstract
1. Urinary metabolites of dimethylamphetamine after oral administration to rat and healthy human volunteers have been studied. 2. Six metabolites and unchanged drug were detected in rat urine and the same metabolites except p-hydroxyamphetamine were found in human urine. The major metabolite was dimethylamphetamine N-oxide in both cases, and methamphetamine and amphetamine were also excreted as minor metabolites. 3. Metabolites excreted in three days after administration of the drug to rat amounted to about 57% of the dose and those after administration to man, 53–56%.This publication has 7 references indexed in Scilit:
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