COMPARATIVE PATHOLOGY STUDY OF MYOCARDIAL LESIONS AND ATHEROSCLEROSIS IN JAPANESE MEN LIVING IN HIROSHIMA, JAPAN AND HONOLULU, HAWAII

  • 1 January 1976
    • journal article
    • research article
    • Vol. 34  (6) , 592-600
Abstract
Autopsies were conducted on Japanese men from 45-71 yr of age in Hiroshima, Japan (191 patients) and in Honolulu, Hawaii, USA (298 patients). They were performed according to a common protocol. In both locations the patients sutdied were representative of decedents from population-based cohorts with respect to age and cause of death. The degree of atherosclerosis in the coronary arteries and aorta, assessed according to the panel method, was substantially more severe in men in Hawaii than in those in Japan. Areas of recent myocardial necrosis were 3.5 times more frequent in men in Honolulu than in those in Hiroshima. Large myocardial scars were 1.5 times more frequent in the men in Honolulu. Among men in Honolulu, severe atherosclerosis and myocardial lesions characteristically appeared at younger ages than in those in Hiroshima. There is an increase in the frequency and severity of ischemic lesion in the myocardium of Japanese who migrate to Hawaii and this increase is the result of atherosclerosis of the extramural segments of the coronary arteries.

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