AMELIORATION OF CIS-PLATINUM NEPHROTOXICITY BY ORGOTEIN (SUPEROXIDE-DISMUTASE)

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 10  (3) , 267-277
Abstract
In rats, daily administration of a s.c. dose of 2.5 mg/kg of orgotein, the pharmaceutical preparation of Zn-Cu superoxide dismutase, lowered the nephrotoxicity induced by a 5.0 mg/kg dose of the antitumor agent cis-platinum (cis-diaminedichloroplatinum II). The toxicity of cis-platinum was studied by comparative measurements of blood urea nitrogen and changes in body weight, and by comparative renal histology. In addition to their direct clinical applicability, these results support a role for pathologic levels of oxygen radicals in the etiology of the nephrotoxocity of cis-platinum.