Effect of Calcitonin on Serum Gastrin Concentration and Component Pattern in Man
- 1 July 1975
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 41 (1) , 149-152
- https://doi.org/10.1210/jcem-41-1-149
Abstract
Synthetic salmon calcitonin (sCT, doses of 0.7 Medical Research Council U per kg) was injected into nine normal subjects and three patients with hypergastrinemia (pernicious anemia). sCT depressed basal as well as food-stimulated serum gastrin concentrations without concomitant changes in total and ultrafiltrable concentrations of calcium in serum. Gel filtration of sera revealed that sCT reduced mainly the small components, III (gastrin-17 or “little” gastrin) and IV (gastrin-13 or “mini”-gastrin).Keywords
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