INVIVO TURNOVER STUDIES OF C-REACTIVE PROTEIN AND LIPOPROTEINS IN THE RABBIT

  • 1 January 1984
    • journal article
    • research article
    • Vol. 58  (1) , 245-252
Abstract
Clearance from the plasma of 125I-labeled rabbit C-reactive protein (CRP) was significantly slower in animals undergoing an acute phase response (T1/2 [half-time], mean .+-. SD, 6.48 .+-. 1.4 h, n = 4) than in normal rabbits (3.17 .+-. 0.4 h, n = 4), P < 0.01. In contrast, there was no difference between the rates of clearance of CRP in rabbits on a normal diet and hypercholesterolemic rabbits, the plasma of which contained high levels of .beta.-VLDL [very low density lipoprotein] with which CRP is known to form circulating complexes. The apparent rates of clearance of 125I-labeled .beta.-VLDL, VLDL and LDL [low density lipoprotein] did not differ between normal rabbits and rabbits undergoing an acute phase response. The significance of these findings is discussed.