THE EQUILIBRIA BETWEEN NATIVE AND DENATURED HEMOGLOBIN IN SALICYLATE SOLUTIONS AND THE THEORETICAL CONSEQUENCES OF THE EQUILIBRIUM BETWEEN NATIVE AND DENATURED PROTEIN

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Abstract
A theoretical treatment is given of the rate of escape of hemoglobin from the hemolyzed red corpuscle. For complete permeability of the surface, as may perhaps be produced by strong lysins, the time taken for the hemoglobin to decrease to 10 per cent of its original concentration is calculated to be 0.16 seconds (for the human cell). For dilute saponin, giving complete lysis of human cells in 3 minutes, Ponder found a time of escape of 4 seconds, from which the permeability of the membrane to the pigment is calculated to be µH = 5 x 10–5 cm./sec.

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