Fibrinolytic Split Products

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Abstract
Fibrinolytic split product (FSP) levels were correlated with renal biopsy results in 25 adults with lupus glomerulonephritis and 23 adults with other renal diseases. The FSP levels were elevated in 42 of the 48 patients. Other coagulation studies showed increased plasma fibrinogen levels in 29 of 33 patients, positive ethanol gelation reactions, and prolonged prothrombin, thrombin, or plasma clot times. All platelet counts were normal or slightly elevated. In glomerular capillaries of lupus nephritis patients, elevated FSP levels correlated best with fibrinoid presence, and, to a lesser degree, with fibrin. There were no relationships between FSP levels and glomerular lesions in patients with other renal diseases. Although there was reliable clinical and pathologic evidence for intravascular coagulation in these renal disease patients, the pathogenetic role of intravascular coagulation in destructive and progressive renal lesions in man remains unknown.