Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
Open Access
- 12 July 2007
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 7 (1) , 126
- https://doi.org/10.1186/1471-2407-7-126
Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist and is frequently inactivated by promoter methylation in many human cancers. However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear.Keywords
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