EVALUATION OF THE SAFETY AND EFFICACY OF BUPROPION IN DEPRESSION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (5) , 101-103
Abstract
A placebo-controlled double-blind study was conducted to test the antidepressant effects of bupropion at dosage levels of 300 or 450 mg/day. Subjects were 30 hospitalized primary major depressives who were treated for 4 wk. Physical and behavioral measures were obtained at baseline and at the end of each experimental week. The combined results of the 2 bupropion groups were significantly better than placebo. Preliminary results showed a significant antidepressant effect of the 300 mg/day dose, but not the 450 mg/day dose, compared to placebo. Anxiety symptoms were also somewhat reduced by the 300 mg/day dose. The results are compared with those of a previous study which utilized higher dosages.