ABNORMALITIES OF LIVER-FUNCTION FOLLOWING EXTENSIVE JEJUNOILEAL BYPASS AND RESECTION IN RATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 81  (5) , 578-582
Abstract
A greater than 90% jejunoileal bypass similar to the type performed in man for morbid exogenous obesity was performed in 70 adult female Wister rats; in an additional 70 rats a greater than 90% jejunoileal resection was performed. The control group consisted of 46 rats, which were not subjected to any experimental measures. Following operation the bypass group demonstrated a significantly greater weight loss than did the resection group. Total plasma protein, albumin and glutamic oxalacetic transaminase all decreased from the control in the resection and bypass groups; the decrease was more significant in the bypass than in the resected group. These results suggest the possible production of a hepatotoxic factor in the excluded small bowel segment.