Increased concentrations of liver cholesterol in rats fed lactulose (Short communication)

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Abstract
The disaccharide lactulose (β‐D‐galactopyranosyl‐(1‐4)‐D‐fructofuranose) is thought to be poorly hydrolized by intestinal enzymes but is broken down by microorganisms in the colon. Thus lactulose shares with pectin similar characteristics [1]. Lactulose is used in the food industry and in the treatment of constipation. There is preliminary evidence that dietary lactulose (5%, w/w) causes increased cocentrations of serum and her cholesterol in rats when compared with pectin [2]. This paper describes dose‐response relationships between dietary lactulose and cholesterol in either serum or liver.