ADDISON'S DISEASE ASSOCIATED WITH THYROID INSUFFICIENCY AND ATROPHY (SCHMIDT SYNDROME)

Publisher Website
Google Scholar
Abstract
Thirty-five cases of Addison''s disease are reviewed. Presence of pituitary insufficiency was ruled out by clinical and laboratory evaluation and autopsy findings. Twelve postmortem examinations were made. Four autopsy cases showed absence or almost complete destruction of the thyroid and 4 others showed extensive destruction by lymphocytic infiltration, fibrosis and atrophy of thyroid acini. Nine of the 35 patients were clinically hypothyroid, and many of the others showed symptoms which could be attributed to hypothyroidism; 7 showed definite laboratory evidence of hypothyroidism. In 2 patients with clinical evidence of myxedema, tests showed normal thyroid function; but in 4 patients whose tests showed abnormal thyroid function there was no clinical evidence of hypothyroidism. Thus in 13 cases there was either clinical or laboratory evidence of hypothyroidism, and in almost all there were some clinical laboratory or anatomic thyroid abnormalities.

This publication has 2 references indexed in Scilit: