Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses

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Abstract
Mouse strain G was studied for its susceptibility to various strains of murine leukemia and sarcoma viruses. N- and NB-tropic Friend leukemia viruses did not induce splenomegaly or grow efficiently in strain G mice. Using the XC [rat sarcoma cells] test, cultured embryo cells were found to be resistant, but not absolutely, to all the tested viruses, N-tropic AKR virus, N- and NB-tropic Friend leukemia viruses, NB-tropic Rauscher leukemia virus, B-tropic WN1802B virus, NB-tropic Moloney leukemia and sarcoma viruses and N-tropic Kirsten sarcoma virus, although the resistance to Moloney leukemia and sarcoma viruses is sometimes not as strong as that for other viruses. Thus, strain G mice are unique among mouse strains because they show resistance that is not related to the N-B tropism of murine leukemia viruses.