[Influence of benzbromarone on the pharmacokinetics and pharmacodynamics of oxipurinol].

  • 1 January 1982
    • journal article
    • abstracts
    • Vol. 32  (9) , 1149-52
Abstract
1. When giving 100 mg allopurinol and 20 mg benzbromarone in a fixed combination we found that the oxipurinol levels differed at 0 and after 4 h from those after administration of 100 mg allopurinol; the oxipurinol clearance is increased; benzbromarone increased the glomerular filtration rate as well as the urine volume. 2. The urate serum levels are decreased under additional administration of benzbromarone, the urate clearance is increased; urate levels in serum dropped slower than under monotherapy with alloprinol and increased again within the last 12 h.

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