Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue
- 1 October 1971
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 124 (4) , 695-700
- https://doi.org/10.1042/bj1240695
Abstract
1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)5 (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)6 (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with protocollagen proline hydroxylase. 2. The two model peptides were hydroxylated equally. The results suggest that the hydroxyl group of hydroxyproline contained in the N-terminal region of the peptide has no effect on the enzymic hydroxylation of the model peptide.Keywords
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