Antibody Response of Adult Chickens to Infectious and Noninfectious Foot-and-Mouth Disease Virus

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Abstract
Summary: Lesions suggestive of infection were observed in or on the mouth, combs and feet of chickens inoculated with Type A-119 virus propagated in tissue culture. Lesions were not observed in chickens inoculated with Type A-GB virus propagated in guinea pig footpads. A high titer of neutralizing antibody was induced in adult chickens by inoculation of 1 and 2 ml of either infectious or noninfectious Type A-119 virus grown in tissue culture. Infectious Type A-GB, propagated in guinea pig pads, produced a relatively low titer of neutralizing antibody in chickens. Both strains, 119 and GB, of infectious Type A virus produced a good response of complement-fixing antibody in chickens as tested by a modified direct complement fixation test. No evidence of infection was found in normal chickens held with infected birds in the same cage.