Dose-Dependent Immune Response toMycobacterium bovisBCG Vaccination in Neonates

1 February 2007

journal article
Published by American Society for Microbiology in Clinical and Vaccine Immunology

Vol. 14 (2) , 198-200
https://doi.org/10.1128/cvi.00309-06

Abstract

In 10-week-old infants vaccinated at birth with JapaneseMycobacterium bovisBCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4⁺T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4⁺T-cell frequency after 12 h of BCG stimulation.

Keywords

This publication has 25 references indexed in Scilit:

Protection against an aerogenic Mycobacterium tuberculosis infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses
Vaccine, 2006
Mycobacterium bovis BCG Substrains Confer Different Levels of Protection against Mycobacterium tuberculosis Infection in a BALB/c Model of Progressive Pulmonary Tuberculosis
Infection and Immunity, 2006
The Immune Response to BCG Vaccination of Newborns
Annals of the New York Academy of Sciences, 2005
Increased Interleukin‐4 Production by CD8 and γδ T Cells in Health‐Care Workers Is Associated with the Subsequent Development of Active Tuberculosis
The Journal of Infectious Diseases, 2004
The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-γ) but not IFN type I
Mechanisms of Ageing and Development, 2004
Single Intranasal MucosalMycobacterium bovisBCG Vaccination Confers Improved Protection Compared to Subcutaneous Vaccination against Pulmonary Tuberculosis
Infection and Immunity, 2004
Investigation of the Relationships between Immune‐Mediated Inhibition of Mycobacterial Growth and Other Potential Surrogate Markers of ProtectiveMycobacterium tuberculosisImmunity
The Journal of Infectious Diseases, 2002
Inherited disorders of IL-12- and IFNγ-mediated immunity: a molecular genetics update
Molecular Immunology, 2002
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Annual Review of Immunology, 2002
Gamma Interferon-Producing CD4⁺T Lymphocytes in the Lung Correlate with Resistance to Infection withMycobacterium tuberculosis
Infection and Immunity, 2001