Therapy of Seminal Inadequacy I. Use of Pituitary, Chorionic and Equine Gonadotropins1

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Abstract
Twenty-one members of childless couples with seminal inadequacy, whose ages ranged from 27 to 43 yrs. and the duration of whose sterile matings ranged from 2-15 yrs., were investigated and treated with various gonadotrophins. 12 patients presented no signs of andrologic disease, 4 had partial atrophy of one or both testes; 5 gave evidence of chronic epididymitis and/or prostatitis. None presented symptoms or signs of pituitary disease or androgenic deficiency. The following therapeutic schedules were employed: (avg. series comprised 6 wks. of daily injs.) chorionic gonadotrophin, 16 series, avg. dosage for series 12,600 I.U., pituitary gonadotrophin. 11 series, avg. dosage for series 10,800 R.U., equine gonadotrophin, 8 series, avg. dosage for series 9,700 I.U., and in addition 6 combined series of pituitary and chorionic gonadotrophin and 5 combined series of equine gonadotrophin and testosterone propionate. Analysis of treatment data which took into account spontaneous fluctuations of values of various seminal factors, failed to establish any significant enhancement of seminal values relatable to therapy, despite the fact that the wives of 4 patients became pregnant.

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