Angiotensin Blockade in Coarctation of the Aorta

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Abstract
Coarctation of the thoracic aorta is a well established cause of arterial hypertension. Participation of the renin-angiotensin system in the hypertension due to coarctation of the aorta has been suggested1 , 2 and denied.3 4 5 The availability of specific peptide antagonists of the renin-angiotensin system for clinical investigation permits direct assessment of the role of the renin-angiotensin system in clinical hypertension.6 7 8 The use of a competitive inhibitor of angiotensin II action, sarala1 8 angiotensin II (saralasin), has been successful in demonstrating the participation of the renin-angiotensin system in malignant and renovascular hypertension.6 , 7 We present observations on the use of saralasin in two patients with . . .